Lactobacillus reuteriinduces gut intraepithelial CD4+CD8αα+T cells
نویسندگان
چکیده
منابع مشابه
Lactobacillus reuteri induces gut intraepithelial CD4+CD8αα+ T cells.
The small intestine contains CD4+CD8αα+ double-positive intraepithelial lymphocytes (DP IELs), which originate from intestinal CD4+ T cells through down-regulation of the transcription factor Thpok and have regulatory functions. DP IELs are absent in germ-free mice, which suggests that their differentiation depends on microbial factors. We found that DP IEL numbers in mice varied in different v...
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ژورنال
عنوان ژورنال: Science
سال: 2017
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.aah5825